Autologous conditioned plasma

Autologous conditioned plasma (ACP) is a platelet-rich plasma that is extracted from autologous blood using centrifugation. It can support regeneration in a variety of orthopedic conditions and surgical procedures

In an increasing number of orthopedic treatments, for example in the case of tendon and ligament injuries, torn muscles and osteoarthritis, there is growing interest in autologous blood products. In this therapy approach, substances occurring naturally within the body known as growth factors promote healing.

Autologous Conditioned Plasma (ACP) is an autologous blood plasma ‒ occurring naturally within the body ‒ that is conditioned as part of a special production process, which means that it is largely separated from the other blood components (such as erythrocytes), and concentrated. ACP is a platelet-rich plasma (PRP). PRP is a general term for a type of plasma that contains an increased concentration of thrombocytes (in comparison with whole blood) and that is extracted from whole blood using a separation process. Main components of ACP include thrombocytes (platelets), and several growth factors that play an important role in the healing process. Unlike other platelet-rich plasma formulations, ACP is distinguished by a low concentration of white blood cells such as neutrophil granulocytes that can be detrimental to the healing process when present in high concentrations.

ACP is extracted from autologous blood. For this purpose, a small quantity of blood (10 - 15 ml) is drawn from a superficial vein (such as the antecubital in the same way as in the case of a blood test. In a second step, a centrifuge is used to separate the ACP from the other blood components. For this purpose, centrifugation only needs to be carried out for a short interval at low speed. In the next step, the ACP can be separated as a supernatant. Manufacturers such as Arthrex offer dedicated syringe systems for this purpose that can be used to take blood from the patient, it, and then inject it again into the region to be treated. In this respect, the blood product remains in the syringe system throughout the entire process, offering the maximum possible level of protection against contamination.

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