Athletics at the 2012 Summer Paralympics – Men's 4 × 100 metres relay T42-46

The Men's 4x100m Relay athletics events for the 2012 Summer Paralympics took place at the London Olympic Stadium on 5 September. A total of two events were contested over this distance incorporating six different classifications.

South Africa won with a world record time of 41.78 seconds. The team included Samkelo Radebe on the first leg, Zivan Smith on the second leg, Arnu Fourie on the third leg and Oscar Pistorius on the anchor leg.