The Men's 400 metres hurdles at the 2010 Commonwealth Games as part of the athletics programme was held at the Jawaharlal Nehru Stadium on Saturday 9 October and Sunday 10 October 2010.
The top two runners in each of the initial three heats automatically alongside the two fasters runners qualified for the final.
First 2 in each heat (Q) and 2 best performers (q) advance to the Final.