The Para Sport - Men's 100 metres (T46) at the 2010 Commonwealth Games as part of the athletics programme was held at the Jawaharlal Nehru Stadium on Thursday 7 October 2010.
First 3 in each heat (Q) and 4 best performers (q) advance to the Semifinals
First 3 in each heat (Q) and 2 best performers (q) advance to the Final