The men's 100 metres event at the 1999 Pan American Games was held July 24–25.
Qualification: First 2 of each heat (Q) and the next 2 fastest (q) qualified for the final.
Wind: Heat 1: +1.6 m/s, Heat 2: -1.0 m/s, Heat 3: -0.5 m/s
Wind: +0.4 m/s