Asprosin

Fibrillin 1
Identifiers
Symbol	FBN1
Entrez	2200
HUGO	3603
OMIM	134797
RefSeq	NP_000129
UniProt	P35555
Other data
Locus	Chr. 15 q21.1

Asprosin is a protein hormone produced by mammals in their fatty (white adipose) tissues that stimulates the liver to release glucose into the blood stream. In these tissues, asprosin is encoded by the gene FBN1, which also encodes the protein fibrillin. In the liver, asprosin activates rapid glucose release via a cyclic adenosine monophosphate (cAMP) dependent pathway. People with Marfan lipodystrophy syndrome (MFLS) are deficient in asprosin, while people with insulin resistance and obesity have it in abundance.

Asprosin is a protein hormone that has been found to be produced by white adipose tissue in mammals; it is transported to the liver, where it stimulates the release of glucose into the blood stream, via a cAMP-dependent pathway.

Glucose released by the liver into the blood stream is required for the normal function of the brain and other organs, as well as for survival during fasting and other aspects of mammalian function. People with Marfan lipodystrophy syndrome are deficient in asprosin, while people presenting the condition of insulin resistance and obesity produce it in abundance.

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