Aryldialkylphosphatase
| aryldialkylphosphatase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.8.1 | ||||||||
| CAS number | 117698-12-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| Search | |
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
| Phosphotriesterase family | |||||||||
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Structure of organophosphorus hydrolase
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| Identifiers | |||||||||
| Symbol | PTE | ||||||||
| Pfam | PF02126 | ||||||||
| InterPro | IPR001559 | ||||||||
| PROSITE | PDOC01026 | ||||||||
| SCOP | 1dpm | ||||||||
| SUPERFAMILY | 1dpm | ||||||||
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| Available protein structures: | |
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| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
Aryldialkylphosphatase (EC 3.1.8.1) (also known as organophosphorus hydrolase, phosphotriesterase, and paraoxon hydrolase) is an enzyme that hydrolyse organophosphates:
Thus, the two substrates of this enzyme are aryldialkylphosphate and H2O, whereas its two products are dialkylphosphate and aryl alcohol.
Organophosphate is the general name for esters of phosphoric acid and is one of the organophosphorus compounds. They can be found as part of insecticides, herbicides, and nerve gases, amongst others. Some less-toxic organophosphates can be used as solvents, plasticizers, and EP additives.
Bacteria such as Pseudomonas diminuta harbor a plasmid that carries the gene for aryldialkylphosphatase (EC 3.1.8.1). This enzyme has attracted interest because of its potential use in the detoxification of chemical waste and warfare agents and its ability to degrade agricultural pesticides such as parathion. It acts specifically on synthetic organophosphate triesters and phosphorofluoridates. It does not seem to have a natural occurring substrate and may thus have optimally evolved for utilizing paraoxon.
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