Antony Galione
| Antony Galione | |
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Antony Galione at the Royal Society admissions day in London for new fellows in 2016
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| Born | Antony Giuseppe Galione September 13, 1963 Chelmsford |
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| Alma mater | University of Cambridge (BA, PhD) |
| Thesis | Oscillations in intracellular calcium in the blowfly salivary gland (1989) |
| Doctoral advisor | Michael Berridge |
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Website www |
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Antony Giuseppe Galione (born 1963)FRSFMedSci is Professor of Pharmacology and Wellcome Trust Senior Investigator in the Department of Pharmacology at the University of Oxford.
Galione was educated at Felsted School in Essex and Trinity College, Cambridge where he was awarded a Bachelor of Arts degree in Natural Sciences (Pharmacology) in 1985. He was awarded his PhD in 1989 for research on calcium signalling in the blowfly salivary gland supervised by Michael Berridge.
Galione's research investigates calcium signalling. He established the concept of multiple calcium mobilizing messengers which link cell surface stimuli to release of internal calcium stores, and identified their target two-pore channels (TPCs) and organelles. This has enhanced our understanding of how calcium as a ubiquitous cellular regulator may control a myriad of cellular processes with precision.
He established that cyclic ADP-ribose regulates calcium-induced calcium release and globalization of calcium signals, and that Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous trigger for initiating and coordinating calcium signals, often involving communication between organelles at contact sites.
By developing novel pharmacological, molecular and physiological approaches, he has demonstrated that these messengers and their targets regulate many fundamental pathophysiological cellular processes as diverse as Ebola virus disease infection, fertilisation and embryology, cardiac contractility, T cell activation and neuronal excitability. The discovery of lysosomes as calcium stores mobilized by NAADP has identified an entirely new signalling role for these organelles in health and disease.
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