Antigone (Greek: Ἀντιγόνη) was a Macedonian noblewoman that lived in the 4th century BC.
She was the child born to the nobleman Cassander by unnamed mother. Antigone was a relative to the powerful Regent Antipater as she was his niece. Her father and paternal uncle were the sons of Iolaus and through her father Antigone was a distant collateral relative to the Argead dynasty.
Antigone was originally from either Paliura or Eordeaea. Little is known on her life. Antigone married a Macedonian nobleman from obscure origins called Magas who was from Eordeaea. Antigone and Magas lived in Eordeaea and had a daughter called Berenice I of Egypt.
The colony of Antigonia was named after her and her granddaughter of the same name. Her namesake was the first wife of the Macedonian King Pyrrhus of Epirus.