Anti-topoisomerase antibody

Systemic sclerosis

tyrosine phos-
phatase type 22 PTPN22

Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I).

Anti Scl-70 antibodies (also called anti-topoisomerase I after the type I topoisomerase target) is a type of anti-nuclear autoantibody seen mainly in diffuse systemic scleroderma, but is also seen the more limited form of systemic scleroderma called CREST syndrome. However, CREST syndrome is more closely associated with Anti-centromere antibodies. Scl-70 antibodies are associated with more severe scleroderma disease.

Anti-topoisomerase antibodies can be classified according to their immunoglobulin class (IgM, IgG or IgA). IgG-ATA is found most frequently in scleroderma, with IgA being quite common but IgM very infrequent.

Topoisomerase I is an enzyme that relaxes the strain on DNA by nicking and ligating the DNA. ATA inhibits the activity of this enzyme. Since this activity occurs in the nucleus of the cell ATA is a form of anti-nuclear antibody. Scleroderma results from the overproduction of collagen in affected tissues, one study claims that there is an increased density of Topoisomerase I sites in the collagen genes, and that the antibodies may be altering transcription at these loci. ATA correlates with rapid progression of disease.

In systemic lupus erythematosus ATA are associated with nephritis.

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Wikipedia