Rendon is the second son of Rene and Bridget Rendon and is of Mexican descent. His parents say Rendon started playing baseball at a very early age; hitting pine cones with sticks as early as the age of three. Rendon grew up on the southwest side of Houston and excelled academically and in sports. He was a star basketball player, track athlete and baseball player at Hodges Bend Middle School. For the first two and a half years of high school, Rendon attended George Bush High School, before transferring to Lamar High School. As a senior, he was a first team 5A all-state shortstop and an All-Greater Houston selection by the Houston Chronicle after he hit .570 with eight home runs, 17 doubles, 56 Runs batted in, 56 runs scored and 13 stolen bases. Out of high school, Rendon was drafted in the 27th round of the Major League Baseball Draft by the Atlanta Braves. He turned down their signing bonus to play for Rice University and head coach Wayne Graham.

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