Sir Anthony Irby (9 January 1577 – 1610 or 1623) was an English politician.
He was the eldest surviving son of Anthony Irby and his wife Alice Tash (née Alice Welbye), daughter of Thomas Welbye.
Irby was knighted by James I on 23 July 1603. He was an investor in the Virginia company. Some sources state he was MP for Boston in 1604, but that was probably his father.
According to Collins he died aged 32 in 1610 and is buried in Whaplode church, where he has a 10-poster tomb. In February 1603, he had married Elizabeth Peyton, third daughter of Sir John Peyton. They had three sons and two daughters. His oldest son Anthony was Sheriff of Lincolnshire and represented Boston in the Parliament of England.
The inscription on the tomb reads: "Heere lieth buried Sr Anthonie Irby Knight sonne of Anthonie Irby esquire and Alice his wife daughter of Thomas Welbie esquire which Sr Anthonie tooke to wife, Elizabeth daughter of Sr John Peyton of Iselham in the countie of Cambridge knight and baronet of the noble race of the Uffordes sometimes Earls of Suffolk by whome he had issue Sr Anthonie Irby knight Edward Thomas Alice and Elizabeth who died an infant; Sr Anthonie the eldest married his first wife Fraunces daughter of Sir William Wray knight and baronet and Fraunces bis wife daughter and coheire to Sir William Drury of Halsted in Suffolk; his second Margaret daughter of Sr Richard Smith of the countie of Kent knight."