Anovulatory menstrual cycle

The anovulatory cycle is a menstrual cycle characterized by varying degrees of menstrual intervals and the absence of ovulation and a luteal phase. In the absence of ovulation, there will be infertility.

While the normal menstrual cycle in the human typically lasts 4 weeks (28 days, range 21–35 days) and consists of a follicular phase, ovulation, and a luteal phase, followed by either menstruation or pregnancy, the anovulatory cycle has cycle lengths of varying degrees. In many circumstances, menstrual intervals are prolonged exceeding 35 days leading to oligomenorrhea (cycle >35 – 180 days interval), or even longer, amenorrhea. In other cases, menstruation may be fairly regular (eumenorrhea), or more frequent (intervals < 21 days), or there may be a loss of menstrual pattern (menorrhagia, dysfunctional uterine bleeding).

Normal menstrual bleeding in the ovulatory cycle is a result of a decline in progesterone due to the demise of the corpus luteum. It is thus a progesterone withdrawal bleeding. As there is no progesterone in the anovulatory cycle, bleeding is caused by the inability of estrogen — that needs to be present to stimulate the endometrium in the first place — to support a growing endometrium. Anovulatory bleeding is hence termed estrogen breakthrough bleeding.

A physician needs to investigate the cause of anovulation. Common causes are:

With excessive or prolonged bleeding the diagnosis has to be made by a physician on a speedy basis. Other causes of gynecological bleeding need to be excluded, specifically bleeding related to pregnancy, leiomyoma, and cancer of the cervix or uterus.

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