Angelman's syndrome
| Angelman syndrome | |
|---|---|
| Synonyms | Happy puppet syndrome |
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| "Boy with a Puppet" or "A child with a drawing" by Giovanni Francesco Caroto | |
| Pronunciation | |
| Specialty | Medical genetics |
| Symptoms | Delayed development, happy, intellectual disability, speech problems, balance and movement problems, small head, seizures |
| Usual onset | Noticeable by 6–12 months |
| Causes | Genetic (new mutation) |
| Diagnostic method | Based on symptoms, genetic testing |
| Similar conditions | Mowat-Wilson syndrome, Adenylosuccinate lyase deficiency, Pitt-Hopkins syndrome |
| Treatment | Supportive care |
| Prognosis | Nearly normal life expectancy |
| Frequency | 1 in 12,000 to 20,000 people |
| Classification | |
|---|---|
| External resources |
Angelman syndrome (AS) is a genetic disorder that mainly affects the nervous system. Symptoms include a small head and a specific facial appearance, severe intellectual disability, developmental disability, speech problems, balance and movement problems, seizures, and sleep problems. Children are usually happy in nature and have a particular interest in water. The symptoms generally become noticeable by a year of age.
Angelman syndrome is typically due to a new mutation rather than one inherited from a person's parents. Angelman syndrome is due to a lack of function of part of chromosome 15 inherited from a person's mother. Most of the time, it is due to a deletion or mutation of the UBE3A gene on that chromosome. Occasionally, it is due to inheriting two copies of chromosome 15 from a person's father and none from their mother. As the father's versions are inactivated by a process known as genomic imprinting, no functional version of the gene remains. Diagnosis is based on symptoms and possibly genetic testing.
No cure is available. Treatment is generally supportive in nature. Anti-seizure medications are used in those with seizures. Physical therapy and bracing may help with walking. Those affected have a nearly normal life expectancy.
AS affects 1 in 12,000 to 20,000 people. Males and females are equally frequently affected. It is named after a British pediatrician, Harry Angelman, who first described the syndrome in 1965. An older term, "happy puppet syndrome", is generally considered pejorative.Prader–Willi syndrome is a separate condition, caused by a similar loss of the father's chromosome 15.
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