Amphetamine psychosis

Stimulant psychosis
Classification and external resources
Specialty	psychiatry
ICD-10	F14.5 & F15.5
ICD-9-CM	292.1
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Stimulant psychosis is a psychosis symptom which typically occurs following an overdose on psychostimulants, but it also occurs in approximately 0.1% of individuals within the first several weeks after starting amphetamine or methylphenidate therapy.

The most common causative agents are substituted amphetamines and cocaine.

The symptoms of stimulant psychosis may vary slightly depending on the drug ingested but generally include the symptoms of organic psychosis including hallucinations, delusions, and thought disorder.

Drugs in the class of amphetamines, or substituted amphetamines, are known to induce "amphetamine psychosis" typically when chronically abused or used in high doses. In an Australian study of 309 active methamphetamine users, 18% had experienced a clinical level psychosis in the past year. Common amphetamines include cathinone, DOM, ephedrine, MDMA, methamphetamine, and methcathinone though a large number of such compounds have been synthesized. Methylphenidate is sometimes incorrectly included in this class.

The symptoms of amphetamine psychosis include auditory and visual hallucinations, delusions of persecution, and delusions of reference concurrent with both clear consciousness and prominent extreme agitation. A Japanese study of recovery from methamphetamine psychosis reported a 64% recovery rate within 10 days rising to an 82% recovery rate at 30 days after methamphetamine cessation. However it has been suggested that around 5–15% of users fail to make a complete recovery in the long term. Furthermore, even at a small dose, the psychosis can be quickly reestablished. Psychosocial stress has been found to be an independent risk factor for psychosis relapse even without further substituted amphetamine use in certain cases.

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