Aminodeoxychorismate synthase
| 4-amino-4-deoxychorismate synthase | |||||||||
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Aminodeoxychorismate synthase
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| Identifiers | |||||||||
| EC number | 2.6.1.85 | ||||||||
| CAS number | 132264-37-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| Search | |
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
In enzymology, an aminodeoxychorismate synthase (EC 2.6.1.85) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are chorismate and L-glutamine, whereas its two products are 4-amino-4-deoxychorismate and L-glutamate.
It is part of a pathway for the biosynthesis of para-aminobenzoic acid (PABA); a precursor for the production of folates. Folates are family of cofactors that are essential for living organisms. Folate cofactors are used in several one-carbon transfer reactions required during the synthesis of essential metabolites, including methionine and thymidylate.
Aminodeoxychorsimate synthase (PabB), a 51 kDa protein in E. coli, is encoded by the gene pabB. 4-amino-4-deoxychorismate, the product of PabB, can be converted to para-aminobenzoic acid by the enzyme 4-amino-4-deoxychorismate lyase (PabC).
This enzyme belongs to the class of transferases. This means that aminodeoxychorismate synthase catalyzes the transfer of one functional group from a molecule to another. Specifically, aminodeoxychorismate synthase is a transaminase that transfers an amino group to a keto acid. The systematic name is Chorismate:L-glutamine aminotransferase. Formerly aminodeoxychorismate synthase was referred to as PABA synthase; however this name is no longer recommended as it is understood that the formation of PABA requires the action of a further enzyme (4-amino-4-deoxychorismate lyase).
Common names that the enzyme goes by are:
In certain microbial species such as Escherichia coli, aminodeoxychorismate synthase is a heterodimeric complex composed of two proteins, glutamine amidotransferase (PabA) and 4-amino-4-deoxychorismate synthase (PabB). In other species such as plants or lower eukaryotes an enzyme comprising a single polypeptide performs both reactions.
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Wikipedia