AmericanConnection was an American flight connection service brand name for the spoke-hub of U.S. mainline carrier American Airlines, under which regional airline operator Chautauqua Airlines operated feeder flights for American Airlines at its Chicago hub. American Airlines also uses affiliated companies (corporations under common ownership) operating under the American Eagle brand to provide regional service to its other hubs in addition to the AmericanConnection service that was operated by Chautauqua Airlines.

On April 6, 2010, American moved all existing AmericanConnection operations to Chicago-O'Hare as part of its restructuring plan, eliminating service by AmericanConnection at Lambert-St. Louis.

At one time AmericanConnection operated over 180 flights a day to 21 destinations. AmericanConnection was an affiliate member of the Oneworld airline alliance.

Most of the AmericanConnection carriers previously operated under a marketing agreement with TWA Trans World Airlines as TWE Trans World Express banner carriers and later as TWC Trans World Connection marketing during the merger acquisition transition between TWA and American.

RegionsAir operated as AmericanConnection until March 2007 and Trans States Airlines operated as AmericanConnection until May 2009.

Though not associated with TWA as many of former AmericanConnection airlines were, Business Express Airlines was yet another air carrier which flew under the AmericanConnection marketing banner. Prior to its acquisition by AMR Corporation and its integration into the American Eagle destinations route network, Business Express linked many smaller localities directly to American Airlines's expansive national and worldwide route network.

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