Sir Ambrose Cave (died 2 April 1568) was an English politician.
He was the son of Richard Cave (see Cave-Browne-Cave baronets) and Margaret Saxby of Stanford, Northamptonshire and was educated at Cambridge University. He was knighted by 1525.
He was a Member of Parliament for Leicestershire in 1545, 1547 and 1553 and for Warwickshire in 1558, 1559 and 1563 and High Sheriff of Warwickshire in 1549. He was also Chancellor of the Duchy of Lancaster (1558–1569) and Custos Rotulorum of Warwickshire (also 1558–1568).
He married Margery Willington, daughter of William Willington. Their daughter Margaret married Sir Henry Knollys, privateer and MP. His nephew Roger Cave married Margaret, a sister of William Cecil, 1st Baron Burghley.