Amacuzac is a city in the Mexican state of Morelos. It stands at 18°36′N 99°23′W / 18.600°N 99.383°W, at a mean height of 982 metres above sea level.
The city serves as the municipal seat for the surrounding municipality of the same name. The municipality reported 16,500 inhabitants in the year 2000 census and covers a total surface area of 125 km².
Alberto Luna Villegas is the mayor (presidente municipal) of the town (2004).