Alpha-1 blocker
Alpha-1 blockers (also called alpha-adrenergic blocking agents) constitute a variety of drugs that block α1-adrenergic receptors in arteries, smooth muscles, and central nervous system tissues.
The blockade or reduction of epinephrine and norepinephrine binding on alpha adrenoreceptors reduce arteriolar resistance and increase venous capacitance causes a reflex increase in heart rate. Depending on plasma concentration they may cause orthostatic hypotension. Alpha-1 blockers may decrease LDL and triglycerides and increase HDL.
These drugs may be used to treat:
Others include:
Non-selective Adrenergic blockers:
Silodosin shows high affinity and selectivity for α1A adrenergic receptors found in the prostate which ensures that it works quickly and effectively to relieve the symptoms of BPH. Silodosin's low affinity for α1B receptors in the blood vessels is thought to be reflected in its low incidence of orthostatic and vasodilatory side effects.
Tamsulosin is relatively selective for α1a-adrenergic receptors, which are mainly present in the prostate. Hence, it may have a more selective action in BPH with minimal effects on blood pressure.
By reducing α1-adrenergic activity of the blood vessels, these drugs may cause hypotension (low blood pressure) and interrupt the baroreflex response. In doing so, they may cause dizziness, lightheadedness, or fainting when rising from a lying or sitting posture (known as orthostatic hypotension or postural hypotension). For this reason, it is generally recommended that alpha blockers should be taken at bedtime. Additionally, the risk of first dose phenomenon may be reduced by starting at a low dose and titrating upwards as needed.
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