Alexios Palaiologos (Greek: Ἀλέξιος Παλαιολόγος; died 1203) was a Byzantine nobleman, son-in-law of Emperor Alexios III Angelos (r. 1195–1203) and his heir apparent from 1199 to his death. Throughout this time, he was actively involved in the suppression of several revolts and riots against the emperor. Through his daughter, he became one of the progenitors of the Palaiologan dynasty.
Alexios's origins are obscure. His family was wealthy and mostly known as civil and military officials under the Komnenian emperors. Alexios's father was probably the sebastos and megas hetaireiarches George Palaiologos, the son or grandson of Alexios I Komnenos's staunchest supporter George Palaiologos. Through his grandmother, Alexios shared in the blood of the Komnenian house. In circa 1198, Alexios was chosen by Emperor Alexios III, who was without male offspring, to wed his eldest daughter, Irene. She was a widow of Andronikos Kontostephanos, and Alexios Palaiologos was forced to divorce his own beautiful first wife (whose name is unknown) to marry her. The wedding took place in spring 1199 and was accompanied by lavish celebrations. Alexios thus became the imperial heir apparent, and was elevated to the rank of despot. At the same time, the emperor's second daughter Anna, also a widow, was wed to Theodore Laskaris, the future founder of the Empire of Nicaea.
Shortly afterwards, both imperial sons-in-law were sent alongside general Manuel Kamytzes against the rebel Ivanko in Thrace. During this campaign, in the siege of Kritzimos, Alexios's father George was killed. The campaign failed when the Byzantine force was trapped in an ambush and Kamytzes was captured. This success emboldened Ivanko, who now claimed the imperial title. In spring 1200, Alexios III pretended to be willing to begin negotiations, and sent Alexios Palaiologos to meet the rebel. Alexios gave solemn promises of safety, but when Ivanko appeared in the imperial camp, he was arrested and executed. In February of the same year, Alexios had been called upon to help with the riots that broke out in Constantinople in protest against the embezzlement of charitable donations by the prison warden John Lagos. A large mob had taken control of the capital's prisons and opened them, and battled the guards of the emperor, who was away at Chrysopolis. Alexios Palaiologos led troops into the city and suppressed the revolt after inflicting heavy casualties on the populace.