"Ain't It Funny (Murder Remix)" is a song recorded by American entertainer Jennifer Lopez. The song, a remix of "Ain't It Funny", features additional vocals from Ja Rule (Jeffery Atkins), Caddillac Tah, and Ashanti. It was written by Lopez, Atkins, Tah, Cory Rooney, Irving Lorenzo, and Ashanti. Over a reworking of the beat to Craig Mack's "Flava in Ya Ear" (produced by Easy Mo Bee), Lopez sings about "dropping a boyfriend who keeps messing up".

In July 2001, Lopez's number one album J.Lo (2001) was reissued with a Murder Inc remix of one of its original singles, "I'm Real". The R&B murder remix of "I'm Real" was written by Ja Rule, who also features on the track. According to Rule, he initially was "just f[uck]ing around" with the track after Lopez's team gave it to him to remix, but it turned out to be "a hell of a record". The remix was successful, topping the Billboard Hot 100 chart for several weeks. It also helped J.Lo to return to the top ten of the US Billboard 200 album chart. The remix allowed Lopez to crossover from Pop to R&B. Rule said this put her in "another zone" and her fans aren't "gonna want the pop version of J. Lo no more, they gonna want the 'I'm Real' version". The rapper enjoyed working with Lopez and called it a "real collaboration" because he actually worked with her in the studio. The success of "I'm Real (Murder Remix)" lead him to begin working on a remix for "Ain't it Funny" the following August, which would later be announced as the lead single to J.Lo's remix album, J to tha L–O! The Remixes, in December 2001.

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