The Afon Senni is a river in Powys, Wales which rises in the Fforest Fawr section of the Brecon Beacons National Park and flows northwards for 11 kilometres (7 mi) to a confluence with the River Usk at Sennybridge.
The river rises as Blaen Senni to the north of the peak of Fan Nedd and east of Fan Gyhirych (51°51′44″N 3°35′35″W / 51.8621°N 3.5931°W), occupying a deep glacial trough until it reaches the hamlet of Heol Senni. Before reaching Sennybridge (51°56′44″N 3°34′20″W / 51.9455°N 3.5723°WCoordinates: 51°56′44″N 3°34′20″W / 51.9455°N 3.5723°W), it flows past the village of Defynnog, where it is joined on its left bank by its sole significant tributary, the Nant Treweryn (or Treweren).