Advair
Fluticasone propionate (top)
and salmeterol (bottom) |
|
| Combination of | |
|---|---|
| Fluticasone propionate | Glucocorticoid |
| Salmeterol | Long-acting β2 agonist (LABA) |
| Clinical data | |
| Trade names | Advair, Seretide |
| AHFS/Drugs.com | advair |
| MedlinePlus | a699063 |
| Pregnancy category |
|
| Routes of administration |
Inhalation |
| Legal status | |
| Legal status | |
| Identifiers | |
| ATC code | R03AK06 (WHO) |
| PubChem | CID 9811567 |
| ChemSpider |
7987322 
|
The combination preparation fluticasone/salmeterol is a formulation containing fluticasone propionate and salmeterol xinafoate, used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is marketed by GlaxoSmithKline under various trade names including Advair (in the US and Canada), Seretide (Brazil, India, Australia, Colombia, EU, Russia, México, New Zealand, South Africa, South Korea, Turkey, UK, Estonia), Viani (Germany), Adoair (Japan) and Foxair (South Africa). In India it is marketed by Intas under the trade name Quikhale SF. Annual worldwide sales were approximately US$7 billion in 2009. Patent protection in the US expired in 2010, and European patent protection expired in 2013. However, the availability of a generic form of Advair in the United States may be significantly delayed because the Food and Drug Administration has not determined a standard for the bioequivalence of inhaled steroids in multi-dose inhalers or dry powder inhalers.
Fluticasone, a corticosteroid, is the anti-inflammatory component of the combination, while salmeterol treats constriction of the airways. Together, they help prevent symptoms of coughing, wheezing and shortness of breath.
Advair is available in several dosage strengths, depending on the patient's country, as a DPI (dry-powder inhaler). The smallest dosage is 100 μg fluticasone/50 μg salmeterol, the intermediate dosage is 250/50 μg and the highest dosage is 500/50 μg.
Advair HFA aerosol as a MDI (metered-dose inhaler) is available in Canada and the U.S. and now in Australia and New Zealand as Advair HFA 45/21 μg, Advair HFA 115/21 μg, and Advair HFA 230/21 μg. These contain 60 inhalations and are generally prescribed as a 30-day supply (1 inhalation twice a day).
Internationally the fluticasone/salmeterol combination is delivered by a number of devices, including standard aerosol metered dose inhalers (named Evohaler in Mexico and UK) or dry-powder devices (termed Accuhaler in Australia and the UK, Diskus in France and the U.S. and Multidisk in Russia). These purple disk-shaped containers are about 3.5 inches (8.9 cm) across and about 1 inch thick (2.5 cm). The disc container uses a machined 2 piece long foil ribbon with each unit dose held in small caplet-shaped depressions along the entire dose-count-length. Once the lever is actuated the dose is advanced by peeling away the flat outermost layer exposing the medication that is ready to be inhaled.
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Wikipedia