"A Pain That I'm Used To" is the second single and opening track of the album Playing the Angel by Depeche Mode, and the forty-second DM single overall. The single was released on 12 December 2005 by Mute Records. The single contains remixes by UK Mute label mates Goldfrapp, and Jacques Lu Cont (Stuart Price). There are also two radio versions. The first one is only a slight remix, whereas the second contains a completely different, more electronic introduction and instrumentation.

Although "Better Days" was mentioned to be the B-side for the single in its press release, it ended up being a track called "Newborn" when the track lists were released. "Better Days" went on to be the B-side to the following single, "Suffer Well". "Newborn" is a slow song that transforms into a harder song during the chorus. It is a fan-favourite in terms of B-sides.

The single was only physically released in the UK. The US only had a digital release (i.e., iTunes). The song reached number 15 upon UK release. In the US, the song debuted at number 45 on the Hot Dance Music/Club Play chart on 14 January 2006. It eventually reached number 6.

The music video is directed by Uwe Flade, who also directed the "Precious" single. It features much more live action sequences (in a race track), than the "Precious" video and even David Gahan's "Bottle Living" video. Depeche Mode's live drummer Christian Eigner also appears in the video.

The song was featured on the Bones episode THE WOMAN IN THE TUNNEL. It is also featured in the first trailer for the 2010 film The Sorcerer's Apprentice. The Jacques Lu Cont Remix also appears on the soundtrack to EA Sports' 2006 FIFA World Cup video game.

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