ACES (buffer)

ACES (buffer)

Names
IUPAC name 2-(carbamoylmethylamino)ethanesulfonic acid
Other names N-(2-Acetamido)-2-aminoethanesulfonic acid
Identifiers
CAS Number	7365-82-4 N
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:39062 Y
ChemSpider	73843 Y
ECHA InfoCard	100.028.099
PubChem CID	81832
InChI InChI=1S/C4H10N2O4S/c5-4(7)3-6-1-2-11(8,9)10/h6H,1-3H2,(H2,5,7)(H,8,9,10) Y Key: DBXNUXBLKRLWFA-UHFFFAOYSA-N Y InChI=1/C4H10N2O4S/c5-4(7)3-6-1-2-11(8,9)10/h6H,1-3H2,(H2,5,7)(H,8,9,10) Key: DBXNUXBLKRLWFA-UHFFFAOYAH
SMILES C(CS(=O)(=O)O)NCC(=O)N O=S(=O)(O)CCNCC(=O)N
Properties
Chemical formula	C4H10N2O4S
Molar mass	182.199
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YN ?)
Infobox references

ACES is the common abbreviation for the compound N-(2-Acetamido)-2-aminoethanesulfonic acid.

ACES is one of Good's buffers developed in the 1960s to provide buffers with pH ranging from 6.15-8.35 for use in various applications. With a pK_a of 6.9, it is often used as a buffering agent in biological and biochemical research. It is a zwitterionic buffer with a useful buffering range of 6.1-7.5. The pioneering publication by Good and his co-workers described the synthesis and physical properties of ACES buffer.

ACES had been used to develop buffers for both agarose and polyacrylamide gel electrophoresis. ACES use in isoelectric focusing of proteins has also been documented. Use of ACES has been published in a protocol for the analysis of bacterial autolysins in a discontinuous SDS-PAGE system. Potential inhibition of ACES and other Good buffers has been investigated in γ-aminobutyric acid receptor binding to rat brain synaptic membranes.