4-fluoromethamphetamine

4-Fluoromethamphetamine

Legal status
Legal status	AU: S9 (Prohibited) CA: Schedule I DE: Anlage II (Prohibited) UK: Class A
Identifiers
IUPAC name (RS)-1-(4-fluorophenyl)-N-methylpropan-2-amine
CAS Number	351-03-1 N
PubChem CID	11745017
ChemSpider	9919721 Y
UNII	8LLF59DO7F
Chemical and physical data
Formula	C10H14FN
Molar mass	167.223 g/mol
3D model (Jmol)	Interactive image
SMILES Fc1ccc(cc1)CC(NC)C
InChI InChI=1S/C10H14FN/c1-8(12-2)7-9-3-5-10(11)6-4-9/h3-6,8,12H,7H2,1-2H3 Y Key:YCWZPIHKUYZTFM-UHFFFAOYSA-N Y
NY (what is this?)

4-Fluoromethamphetamine (4-FMA) is a stimulant drug related to methamphetamine and 4-fluoroamphetamine. It has been reported to be sold on the illicit market as a controlled substance analogue, but little is known about its pharmacology or toxicology as yet. It was first detected from legal highs sold in Japan in 2006 and became illegal to sell or to possess for the purpose of distribution (although not to simply possess for personal use) in Japan in 2008. It was initially reported to be contained as an ingredient in some of the range of party pills sold internationally by the Israeli company Neorganics from around 2006 onwards, but this was later shown to be incorrect and this ingredient was eventually identified as the closely related compound 2-fluoromethamphetamine.

4-FMA is a CYP450 inhibitor. It reduces the metabolism of methamphetamine, which has the effect of increasing its potency, duration and systemic toxicity while also reducing its cellular toxicity.

As of October 2015 4-FMA is a controlled substance in China.

4-FMA is considered a Schedule 9 substance in Australia under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.