4-O-Methylhonokiol
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IUPAC name
2-(4-Methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
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| Other names
3,5′-Diallyl-2′-hydroxy-4-methoxybiphenyl
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3D model (JSmol)
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| Properties | |
| C19H20O2 | |
| Molar mass | 280.37 g·mol−1 |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
4-O-Methylhonokiol is a neolignan, a type of phenolic compounds. It is found in the bark of Magnolia grandiflora and in M. virginiana flowers.
4-O-Methylhonokiol is a potent CB2 receptor ligand (Ki = 50 nM), showing a unique inverse agonism and partial agonism via different pathways (cAMP and Ca2+) and potently inhibits osteoclastogenesis. 4-O-Methylhonokiol further attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. The different neuroprotective and anti-Alzheimer Disease effects reported in rodent models may be mediated via CB2 receptors, providing that the compound should be orally bioavailable to the brain. It was shown that 4-O-methylhonokiol activates CB2 receptors and also inhibits the oxygenation of the major endocannabinoid 2-AG via COX-2 in a substrate-selective manner, thus leading to potential synergistic effects at CB receptors. The same study also provided data that this natural product can readily pass the blood–brain barrier, using LC-MS/MS.
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