"2 of Amerikaz Most Wanted" is a West Coast hip hop song written by 2Pac, Snoop Doggy Dogg and Daz Dillinger for 2Pac's 1996 double album All Eyez on Me. The song is a duet performed by 2Pac and Snoop Dogg. "2 of Amerikaz Most Wanted" was released as promotional single and was the album's second single after "California Love". The song peaked at number 46 on the US Billboard Hot R&B/Hip-Hop Airplay chart. The song contains an interpolations of "The Message" by Grandmaster Flash and The Furious Five and "Radio Activity Rap (Let's Jam)" by MC Frosty and Lovin' C.

"2 of Amerikaz Most Wanted" was later included on 2Pac's Greatest Hits in 1998. A remix of the song was also featured on the album Nu-Mixx Klazzics in 2003.

The video was directed by one of 2Pac's production partners, Gobi M. Rahimi and was filmed four months prior to September 1996 shooting. The prelude for the song shows a parody of Biggie Smalls ("Piggie") and Puff Daddy ("Buff Daddy") in discussion with Shakur about the November 1994 shooting. The beginning of the scene where Tupac is speaking to Biggie is in reference to the movie Scarface where Tony speaks to his alleged killer before shooting him.

...
Wikipedia