21c Museum Hotel

21c Museum Hotels is a Louisville-based combination contemporary art museum and boutique hotel chain. As of 2017, it manages seven properties in Louisville, Kentucky; Lexington, Kentucky; Cincinnati, Ohio; Bentonville, Arkansas, Durham, North Carolina, Oklahoma City, OK, and Nashville, Tennessee.

21c Museum Hotel was voted among the Top 10 Hotels in the World in the Condé Nast Traveler Readers' Choice Awards in 2009, 2010 and 2011. It was also voted as the No. 1 Hotel in the South in the 2012 Condé Nast Traveler Readers' Choice Awards. 21c Museum Hotel Cincinnati was named the top hotel in America in 2013 by Conde Nast Traveler's annual reader survey, and 11th in the world.

21c Museum Hotel was launched in 2006 by philanthropists and art collectors Laura Lee Brown and Steve Wilson. The pair had seen farmland and rural landscapes fall to development while the historic buildings of Louisville's downtown sat vacant. They created 21c in Louisville's downtown arts and theater district to support both urban renewal and regional agriculture, and have developed partnerships with local growers to supply produce and ingredients for the Proof on Main restaurant and bar.

On June 10, 2010, Brown and Wilson announced plans to build a new 21c hotel in Bentonville, Arkansas. This hotel is being developed in partnership with heirs of Walmart founder Sam Walton. The hotel is located on land that was once a corn field outside of the urban center of Bentonville. The estimated cost of the project is $28 million. It opened in 2013 and will bring an estimated 160 new jobs to the area, which are expected to be filled largely by contracted workers. The opening of the hotel is expected to cause Bentonville to lose half of its current hotel base.