The 2018 Copa Sudamericana final stages are scheduled to be played from 21 August to 12 December 2018. A total of 16 teams compete in the final stages to decide the champions of the 2018 Copa Sudamericana.
The 16 winners of the second stage advance to the round of 16.
Starting from the round of 16, the teams are seeded according to the second stage draw, with each team assigned a "seed" 1–16 corresponding to the tie they win (O1–O16) (Regulations Article 22.c).
Starting from the round of 16, the teams play a single-elimination tournament with the following rules:
The bracket starting from the round of 16 is determined as follows:
The bracket will be decided based on the second stage draw.