2015–16 UEFA Women's Champions League knockout phase

The 2015–16 UEFA Women's Champions League knockout phase began on 7 October 2015 and concluded on 26 May 2016 with the final at Mapei Stadium – Città del Tricolore in Reggio Emilia, Italy, which decided the champions of the 2015–16 UEFA Women's Champions League. A total of 32 teams competed in the knockout phase.

Times from 25 October 2015 up to 26 March 2016 (round of 16 and quarter-finals first legs) were CET (UTC+1), all other times were CEST (UTC+2).

The schedule of the competition was as follows (all draws were held at the UEFA headquarters in Nyon, Switzerland).

The knockout phase involved 32 teams: 24 teams which qualified directly, and the eight group winners from the qualifying round.

Each tie in the knockout phase, apart from the final, was played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, the away goals rule was applied, i.e. the team that scored more goals away from home over the two legs advanced. If away goals were also equal, then 30 minutes of extra time was played. The away goals rule was again applied after extra time, i.e. if there were goals scored during extra time and the aggregate score was still level, the visiting team advanced by virtue of more away goals scored. If no goals were scored during extra time, the tie was decided by penalty shoot-out. In the final, which was played as a single match, if scores were level at the end of normal time, extra time was played, followed by penalty shoot-out if scores remained tied.

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