The 2015–16 season was Società Sportiva Lazio's 115th since their founding and the club's 28th consecutive season in the topflight of Italian football. The club competed in Serie A, the Coppa Italia, and the UEFA Champions League. Having finished 3rd the previous season, Lazio began in the play-off round but failed to qualify after a 3–1 loss on aggregate against Bayer Leverkusen.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

Last updated: 15 May 2016.
Source: Competitive matches

Last updated: 15 May 2016.
Source: Competitive matches
Ground: A = Away; H = Home. Result: D = Draw; L = Loss; W = Win; P = Postponed.

Last updated: 15 May 2016
Source: Competitions

Last updated: 15 May 2016

Last updated: 1 May 2016