The 2015–16 season was Società Sportiva Calcio Napoli's 70th season in Serie A. The team competed in Serie A, the Coppa Italia, and the UEFA Europa League. In Serie A Napoli enjoyed an immense season, finishing in 2nd place and having been in 1st place for much of the mid-season period. Star striker Gonzalo Higuaín became the player with the most goals in a single season in all of Serie A history, with 36 goals, overtaking Gunnar Nordahl's long-standing record of 35. Napoli were eliminated in the quarter-finals of the Coppa Italia by Inter. In the UEFA Europa League, Napoli finished with a perfect 6–0–0 record in the group stage, scoring 22 goals in the process. However, this form did not continue into the knockout phase, where they were eliminated in the round of 32, 2–1 on aggregate by Spanish side and eventual semi-finalists Villarreal.

On 25 May 2015 coach Rafael Benítez was signed by Real Madrid to replace Carlo Ancelotti. Former Empoli manager Maurizio Sarri replaced Benítez on 12 June.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

Total expenditure: €32.2 million

Total revenue: €10.6 million

Net income: €21.6 million

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