2012 Winston-Salem Open – Singles

Singles
2012 Winston-Salem Open
Champion	John Isner
Runner-up	Tomáš Berdych
Final score	3–6, 6–4, 7–6(11–9)
Events
Singles Doubles
← 2011 · Winston-Salem Open · 2013 →

John Isner successfully defended his title by beating Tomáš Berdych 3–6, 6–4, 7–6^(11–9) in the final.

All seeds received a bye into the second round.

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