The 2012 National League Championship Series was a best-of-seven playoff pitting the San Francisco Giants against the St. Louis Cardinals for the National League pennant and the right to play in the 2012 World Series. The series, the 43rd in league history, began Sunday, October 14, and ended Monday, October 22, with Fox airing all games in the United States. The Giants came back from 3–1 deficit and outscored the Cardinals 20–1 over the final three games to win the series 4–3.

This was the third postseason meeting between the Giants and the Cardinals, and also marked the first time in MLB history since the creation of the League Championship Series in 1969 that the last two World Series champions faced off against each other for the pennant. The Giants won in 2010 while the Cardinals won in 2011. Coincidentally, the last two postseason meetings between the two teams occurred in the NLCS, which both ended on October 14, the day of Game 1. The Cardinals won Game 7 of the 1987 NLCS, while the Giants triumphed in the pennant-clinching Game 5 of the 2002 NLCS.

San Francisco won the series, 4–3.

Sunday, October 14, 2012 – 8:15 p.m. (EDT) at AT&T Park in San Francisco, California

The Cardinals scored first in the second inning, with a Yadier Molina single followed by a two-run home run by David Freese. In the fourth inning, Daniel Descalso doubled and scored on a Pete Kozma double; Kozma then stole third base during Lance Lynn's at-bat and scored on a Jon Jay single. With Jay on first, Carlos Beltrán hit a two-run home run to give the Cardinals a 6–0 lead; Giants starting pitcher Madison Bumgarner was then replaced by George Kontos, who got Matt Holliday to pop out to end the inning.

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