The 2012 Chick-fil-A Bowl was a post-season American college football bowl game held on December 31, 2012 at the Georgia Dome in Atlanta in the United States. The 45th edition of the Chick-fil-A Bowl began at 7:30 p.m. EST and aired on ESPN. It featured the Clemson Tigers from the Atlantic Coast Conference (ACC) against the LSU Tigers from the Southeastern Conference (SEC) and was the final game of the 2012 NCAA Division I FBS football season for both teams. Both Tigers accepted an invitation to the game after achieving a 10–2 regular season record.

This was not the first time the two Tigers have met in the Chick-fil-A Bowl; the 1996 game also pitted them against each other, with LSU topping Clemson by a score of 10–7. Their first meeting was the 1958 Sugar Bowl, a national championship, that LSU won in a 7-0 shutout.

Clemson won the game in a 25-24 upset. Despite out-gaining LSU by 445-219 in total yards, Clemson trailed for much of the game. Clemson was able to win after placekicker Chandler Catanzaro made a 37-yard field goal as time expired. Clemson quarterback Tajh Boyd, who completed 36 of 50 passes for 346 yards, was named the game's most valuable player.

The 2012 Chick-fil-A Bowl marked the third meeting between Clemson and LSU, with LSU holding a 2-0 advantage coming into the game. The previous meeting was a 10-7 victory for LSU in the 1996 Chick-fil-A bowl.

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