2012 Bank of the West Classic – Singles
| Singles | |
|---|---|
| 2012 Bank of the West Classic | |
| Champion |
 Serena Williams
|
| Runner-up |
Coco Vandeweghe
|
| Final score | 7–5, 6–3 |
Serena Williams successfully defended her title after defeating lucky loser Coco Vandeweghe in the final, 7–5, 6–3. It was the first all-American final on the WTA Tour since the 2009 WTA Tour Championships and the first on American soil since Los Angeles in 2004.
The top four seeds received a bye into the second round.
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