The 2010 Women's Basketball Invitational was the inaugural year of the tournament, involving the participation of 16 National Collegiate Athletic Association (NCAA) Division I teams that did not participate in the 2010 NCAA Women's Division I Basketball Tournament or 2010 WNIT. WBI guidelines state that the Championship game is hosted by the school with the higher end of the season RPI, and for the first run of this competition, Appalachian State defeated Memphis to emerge as the victor.
The WBI Championship Game was hosted by Appalachian State.