2010 Serbia Open – Singles
| Singles | |
|---|---|
| 2010 Serbia Open | |
| Champion |
 Sam Querrey
|
| Runner-up |
John Isner
|
| Final score | 3–6, 7–6(7–4), 6–4 |
Novak Djokovic was the defending champion, but retired trailing 4-6 in the quarterfinals against Filip Krajinović.
Sam Querrey won in the final 3–6, 7–6(7–4), 6–4 against John Isner.
The first four seeds gets a first-round bye.
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