The 2010 Humanitarian Bowl (officially known as the UDrove Humanitarian Bowl) was the fourteenth edition of the college football bowl game, and was played at Bronco Stadium in Boise, Idaho, on the campus of Boise State University. The game started at 3:30 pm MST on Saturday, December 18, 2010 and was telecast on ESPN. The game featured the Fresno State Bulldogs from the Western Athletic Conference (WAC) versus the Northern Illinois Huskies from the Mid-American Conference (MAC). Despite having been abandoned by their coach of three years, Northern Illinois defeated Fresno State 40–17.

UDrove was the new title sponsor of the game. UDrove is affiliated with the games previous sponsor, Roady's Truck Stops.

Northern Illinois made its third straight bowl appearance and played in a postseason game for the sixth time in the last seven seasons. The Huskies were ranked in the top 25 in the BCS after winning nine straight games and went undefeated in the Mid-American Conference during the regular season. NIU is led by senior running back Chad Spann, who was voted the Mid-American Conference Offensive Player of the Year and took home league MVP honors. Spann led the MAC with 1,293 yards on 226 carries and is tied for second in the Football Bowl Subdivision with 20 rushing touchdowns, a NIU single-season record.

Fresno State was invited to the Humanitarian Bowl after posting an 8–4 regular season record. Fresno State won their season finale against Illinois, 25–23. Since 2000 the Bulldogs have won 17 games against teams from BCS Conferences. This was the 3rd time that Fresno State appeared in the Humanitarian Bowl. They entered the game with a 2–0 record in the bowl game with a 37–34 OT win over Virginia in 2004 and a 40–28 victory over Georgia Tech in 2007.

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