The 2010 American League Championship Series (ALCS) was the best-of-seven game series pitting the winners of the 2010 American League Division Series for the American League Championship. The American League wild card-winning New York Yankees faced the American League West Division champions Texas Rangers. The Rangers won the 2010 ALCS and face the National League champion San Francisco Giants in the 2010 World Series, the franchise's first ever appearance in the World Series. The series, the 41st in league history, began October 15 and ended on October 22. The Rangers had home field advantage in the series, as the wild-card team defers home field advantage in the LDS and LCS regardless of regular-season record.

The Rangers and Yankees had met in the postseason in each of the Rangers' three previous postseason appearances; the Yankees had won all previous meetings, 3–1 in the 1996 ALDS, and 3–0 in the 1998 and 1999 ALDS.

Texas won the series, 4–2.

Friday, October 15, 2010 – 8:00 p.m. (EDT) at Rangers Ballpark in Arlington in Arlington, Texas

The Yankees quickly fell behind as the Rangers got to their ace, CC Sabathia. In the first inning Josh Hamilton cracked a three-run home run to put Texas out in front. Michael Young added two more runs in the fourth with a double. Rangers starter C. J. Wilson had gone for seven strong innings, allowing only a single earned run, a solo homer by Robinson Canó.

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