The 2010–11 season was the 51st season in the history of NK Maribor and the club's 20th consecutive season in the Slovenian PrvaLiga since the league establishment in 1991. The team participated in the Slovenian PrvaLiga, Slovenian Football Cup, and UEFA Europa League. The season covers the period from 1 June 2010 to 31 May 2011. The club started and finished the season with Darko Milanič as a head coach and were crowned as the league champions for the ninth time. They were also runners up of the Slovenian cup and supercup.

The club began their league campaign with a total of 37 points in their first 15 matches, during which time they were undefeated. This set the new all-time league record for the best start of the season, previously held by Domžale (35 points).

The team played its opening match of the seasons in a Supercup final on 9 July 2010, when they lost against Koper after penalties (5–4). The score after regulation was 0–0. Maribor qualified to the final as a Slovenian Cup winner of the previous season. Traditionally, the Supercup final is played on a home stadium of the Slovenian champions, however, this season it was played in Maribor, due to the construction of a new stadium in Koper at the time.

During their Europa League campaign the club had a solid run and played a total of six matches in the competition. Their record was four wins, one draw and one defeat in matches against Videoton, Hibernian and Palermo. The team did particularly well on home field at the Ljudski vrt stadium as they recorded three wins in three matches with a goal difference of 9–2. However, that was not enough for progression as their only defeat came in the first leg of the play-off round against Palermo (3–0). In the second leg Maribor was winning against the Italian side 2–0 after 60 minutes of play, however, the match eventually finished with a 3–2 home victory which was not enough to progress into the main stage of the competition. After the match it was announced that Palermo had acquired Josip Iličić and Armin Bačinović, two of the top players during the club's Europa league campaign.

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