The 2010–11 season was Manchester United's 19th season in the Premier League, and their 36th consecutive season in the top-flight of English football. It was the first season with new shirt sponsors Aon, after four seasons with AIG.

United began the season by beating Chelsea 3–1 at Wembley on 8 August 2010 to claim the Community Shield.

A successful defence of the League Cup would have seen them become only the second team to win the competition for a third successive season, after Liverpool in 1983 (who then went on to win a fourth in 1984). However, their stranglehold on the tournament was broken by West Ham United, who sent an understrength Reds side crashing to a 4–0 defeat at Upton Park in the Fifth Round on 30 November 2010.

On 19 December 2010, Sir Alex Ferguson became the longest-serving manager in Manchester United's history, overtaking Sir Matt Busby's record of 24 years, 1 month and 13 days in charge of the club.

On 1 February 2011, United equalled the club record league unbeaten run of 29 matches, after a 3–1 win over Aston Villa at Old Trafford. They failed to extend the run however, succumbing to a 2–1 defeat against Wolverhampton Wanderers at Molineux on 5 February 2011. This was their first league defeat since 3 April 2010, a 2–1 home defeat by Chelsea. United came close to becoming the first top-flight side in 119 years to win every single home league match during the season, but a draw at home to West Bromwich Albion early in the campaign cost them that status. Their exceptional form at Old Trafford was key to United's eventual title victory, as their away form was surprisingly mediocre, with just five league wins away from home all season.

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