Season 2010–11 for Hibernian was their 12th consecutive season of play in the Scottish Premier League. It was the first season played in the redeveloped Easter Road stadium, with its capacity increased to over 20,000 for the first time since it became an all-seater stadium in the early 1990s. The SPL season began on 15 August 2010 with a 3–2 win at Motherwell. Hibs competed in the UEFA Europa League, losing 6–2 on aggregate to Slovenian club NK Maribor. They also lost at the first stage of competition in the Scottish League Cup, losing 3–1 at Kilmarnock. Those cup defeats and a poor start to the league season led to manager John Hughes leaving by mutual consent in early October.Colin Calderwood was appointed as the new manager, but struggled to make any sort of impression, as they were knocked out of the Scottish Cup by Ayr United and fell into a relegation battle. A winning streak after the January transfer window meant any danger was quickly averted, but the team still finished in the bottom six.

The Edinburgh Evening News reported on 15 May that John Hughes was waiting to see which round Hibs will enter the UEFA Europa League at before finalising his preseason schedule. Dundee United's win in the 2010 Scottish Cup Final confirmed that Hibs will enter in the third qualifying round. Hibs arranged domestic fixtures against Dunfermline Athletic and Queen of the South, a four-game tour of the Netherlands, and visits to Carlisle United and Blackpool either side of their European tie.

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