Only five days after winning the Champions League, on 28 May, Inter manager José Mourinho left the club and joined Real Madrid. On 10 June, Inter signed Rafael Benítez from Liverpool on a two-year contract, ending a six-year stint as manager.

During the summer transfer window, Inter signed Luca Castellazzi from Sampdoria, and also bought the entire rights to Jonathan Biabiany from Parma. After spending his last two season with Vasco da Gama in Brazil, Philippe Coutinho returned to Inter. Inter sold Ricardo Quaresma to Beşiktaş and Mario Balotelli to Manchester City, as well as also sold half of the rights to Rene Krhin to Bologna, Andrea Mei to Piacenza, and sent on one-year loan Vid Belec to Crotone, Victor Obinna to West Ham United and Andrea Ranocchia to Genoa after brought the half of his contract.