The 2010–11 C.D. Motagua season in the Honduran football league was divided into two tournaments, Apertura and Clausura. The preseason started on late June and the Regular season on 7 August 2010.

Before the start of the season, the Honduras national football team competed in the 2010 FIFA World Cup, a total of five Motagua players were call to contribute with the national team, these being Canales, Guevara, Izaguirre, Mendoza and Welcome. Nevertheless, Canales was set free from the team just after returning from the tournament.

On 19 October 2010, coach Ramón Maradiaga separated 8 players from the main squad due to poor performance and sent them to the reserve team. These players were the foreign Guillermo Díaz, Mauricio Weber, Charles Córdoba, and Marcelo dos Santos, leaving the team only with domestic players. Ronald Martínez, Meller Sánchez, Rubén Rivera, and Javier Portillo were also dismissed.

On 4 November 2010, Motagua lost 0–2 at home against C.D.S. Vida, ending any possibilities of advancing to the Final round. This game also set a record of the lowest home attendance of all times for Motagua, with only 97 spectators.

Last updated: 19 November 2010.
Source: Soccerway.com
Ground: A = Away; H = Home. Result: D = Draw; L = Loss; W = Win; P = Postponed.

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