The 2008 NCAA Women's Division I Basketball Tournament involved 64 teams playing in a single-elimination tournament to determine the 2007–08 national champion of women's NCAA Division I college basketball. It commenced on March 22, 2008, and concluded when the University of Tennessee Lady Volunteers defeated the Stanford University Cardinal 64–48 on April 8, 2008 at the St. Pete Times Forum (now known as the Tampa Bay Times Forum) in Tampa, Florida.

The preliminary rounds largely followed the seeding, with every number one and number two seed advancing to the regional finals. In the Greensboro and Oklahoma City Regionals, the top seeds Connecticut and Tennessee won respectively to head to the Final Four. Connecticut had to beat Big East rival Rutgers to make the advance. Tennessee' Candace Parker was injured in the game against Texas A&M and had to leave twice, and be fitted with a sleeve to stabilize her shoulder. She still scored 26 points in a game which was won by only eight.

In the other two regionals, the two seeds prevailed. In the New Orleans Regional, LSU beat North Carolina to reach the Final Four for the fifth consecutive time, tying a record set by Connecticut between 2000 and 2004. In the Spokane Regional, Stanford beat the top seed Maryland to go to their first Final Four since 1997, but one that would be the first of a five-year string of consecutive Final Four appearances.

Connecticut and Stanford met in one semifinal. They had played each other earlier in the season at the Paradise Jam held in St. Thomas, Virgin Islands in November. The Huskies had won that game 66–54, but the team had been at full strength. Subsequent to that game Mel Thomas and Kalana Greene both starters, had season ending injuries. Connecticut cut a Stanford lead to a single point, 47–46 when Candice Wiggins hit two three-pointers to start a 10–0 run. Wiggins would go on to score 25 points in the game and would be named the Women's Basketball Coaches Association national player of the year. The Cardinal went on to win the game, and advance to the national championship.

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