The 2008 Major League Baseball All-Star Game was the 79th midseason exhibition between the all-stars of the American League (AL) and the National League (NL), the two leagues comprising Major League Baseball. The game was played at Yankee Stadium in The Bronx, New York City, home of the New York Yankees, on July 15, 2008 and began at 8:47 p.m. ET. The game ended at 1:38 a.m. ET the following morning. The home American League won 4–3 in 15 innings, giving home field advantage in the 2008 World Series to the AL champion, which eventually came to be the Tampa Bay Rays.

By length of time, this was the longest MLB All-Star Game in history (4 hours and 50 minutes), and it also tied the mark for the longest game by innings played at 15 with the 1967 All-Star Game. Second baseman Dan Uggla of the Florida Marlins committed three errors, an All-Star Game record, none of which resulted in a run. J. D. Drew of the Boston Red Sox was named Most Valuable Player due to his two-run game-tying home run in the seventh inning. Drew won a Chevrolet Tahoe hybrid and the Ted Williams Trophy. It was the second All-Star Game in which the winning run was batted in by the Texas Rangers' Michael Young.

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