In the preseason, Oklahoma was picked by the Big 12 media to finish second in the conference. At the time, the starting quarterback had not been chosen. A little over a week before the first game, freshman quarterback Sam Bradford was announced as the starter. In his first game as a collegiate quarterback, Bradford threw for over 350 yards in the first half, he tied Heisman Trophy winner Jason White's record of 18 consecutive pass completions, and threw for five touchdowns. He came out of the game early in the 3rd quarter. Since then, Bradford led the nation in passing efficiency for most of the season. With the question at quarterback answered, some felt this team could be the best in the nation, but with an unexpected loss at Colorado, the chances were slim. The Sooners continued to play strong following the loss and again rose in the polls as more teams above them also lost. Back in the #3 spot, the Sooners traveled to Lubbock, Texas to take on the Red Raiders to clinch the Big 12 South Division title. However, Bradford was injured on the opening play for the Sooners as they quickly fell behind. It was 27–10 at the halftime. Oklahoma mounted a comeback in the 4th quarter but it was not enough. The Sooners lost their second game and again were knocked out of the national title picture. In their next game against Oklahoma State, in what is referred to as Bedlam, the Sooners dominated winning 49–17 and locking up their spot in the Big 12 Championship Game. In the Big 12 Championship, Oklahoma faced Missouri, then the number one ranked team in the nation. The two faced each other in the regular season in Norman, Oklahoma with the Sooners winning 41–31. The Sooner defense dominated the game and the offense pulled away in the 2nd half. Oklahoma won 38–17 to claim their 5th Big 12 Conference Championship and 41st total conference championship.

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